ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS
Abstract
The peripheral blood count of γδТ cells was investigated in patients with new-onset pulmonary tuberculosis depending on the clinical form of the disease, on Mycobacterium tuberculosis susceptibility to antituberculosis drugs, and on the response to intradermal tuberculin administration (Mantoux test). The count of γδТ cells was shown to decrease in all clinical forms of tuberculosis infection; however, the most significant increase in their count was noted in disseminated and fibrocavernous pulmonary tuberculosis, as well as in the presence of multidrug resistance in Mycobacterium tuberculosis (in infiltrative and fibrocavernous forms of the disease) and a negative response to the Mantoux test in patients with infiltrative pulmonary tuberculosis. The demonstrated decrease in the count of circulating γδТ cells in the blood of patients with pulmonary tuberculosis promotes a reduction in the protective immune response to Mycobacterium tuberculosis.
About the Authors
E. G. Churina
Сибирский государственный медицинский университет
Russian Federation
г. Томск
Russian Federation
г. Томск
O. I. Urazova
Сибирский государственный медицинский университет
Russian Federation
г. Томск
Russian Federation
г. Томск
V. V. Novitsky
Сибирский государственный медицинский университет
Russian Federation
г. Томск
Russian Federation
г. Томск
T. E. Kononova
Сибирский государственный медицинский университет
Russian Federation
г. Томск
Russian Federation
г. Томск
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Review
For citations:
Churina E.G., Urazova O.I., Novitsky V.V., Kononova T.E. ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS. Tuberculosis and Lung Diseases. 2014;(3):59-63. (In Russ.)
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