IN VITRO PHOTODYNAMIC INACTIVATION OF MYCOBACTERIUM TUBERCULOSIS BY RADAHLORIN
https://doi.org/10.21292/2075-1230-2018-96-1-5-10
Abstract
Goal: to detect the best mode of in vitro photodynamic inactivation of M. tuberculosis by Radahlorin.
Subjects and methods. The activity of culture of M. tuberculosis, H37Rv strain, photosensitized by 0.00005% Radohlorin was compared and the intensity of growth was assessed after photodynamic inactivation by different doses of light energy with 662 nm wavelength.
Results. For the first time, anti-microbial properties of E6 chlorine in the form of medicamental photosensitizer (0.00005% Radohlorin) suppressing museum strain of M. tuberculosis of H37Rv were detected. Photoinactivation of M. tuberculosis depends on the dose and achieves its maximum in 10 minutes of light exposure with light energy of 0.5 W.
About the Authors
D. A. Bredikhin
Novosibirsk State University
Russian Federation
Russian Federation
Engineer of Laboratory for Use of Quantum Materials, Devices and Systems
14, Vavilova St., Novosibirsk, 630082
S. D. Nikonov
Novosibirsk Tuberculosis Research Institute; Novosibirsk State University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of Laboratory for Use of Quantum Materials, Devices and Systems
Phone: +7 (383) 225-59-81
A. G. Cherednichenko
Novosibirsk Tuberculosis Research Institut; Novosibirsk State University
Russian Federation
Russian Federation
Senior Engineer of Laboratory for Use of Quantum Materials, Devices and Systems
Phone: +7 (383) 203-83-62
T. I. Petrenko
Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Associate Professor at FPK and PPS Tuberculosis Control Department
81a, Okhotskaya St., Novosibirsk, 630040
Phone: +7 (383) 203-83-58
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Review
For citations:
Bredikhin D.A., Nikonov S.D., Cherednichenko A.G., Petrenko T.I. IN VITRO PHOTODYNAMIC INACTIVATION OF MYCOBACTERIUM TUBERCULOSIS BY RADAHLORIN. Tuberculosis and Lung Diseases. 2018;96(1):5-10. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-1-5-10
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